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Design of an Antibiotic Delivery System Based on a Bioresorbable Bone Substitute
Author(s) -
Vogt S.,
Schnabelrauch M.,
Weisser J.,
Kautz A. R.,
Büchner H.,
Kühn K.D.
Publication year - 2007
Publication title -
advanced engineering materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.938
H-Index - 114
eISSN - 1527-2648
pISSN - 1438-1656
DOI - 10.1002/adem.200700223
Subject(s) - materials science , drug delivery , biocompatibility , bioceramic , calcium carbonate , biomedical engineering , composite number , calcium , fabrication , composite material , nanotechnology , medicine , metallurgy , alternative medicine , pathology
In the current study a new composite material comprising calcium sulphate, calcium carbonate, and tripalmitin was developed as a bioresorbable drug carrier for the local antibiotic therapy. Device fabrication can be simply performed by compression moulding of the components. The evaluated bone substitute material based on a calcium sulphate/calcium carbonate composite exhibits an excellent biocompatibility and a therapeutically useful release profile. It, therefore, represents a promising new antibiotic delivery system for the efficient prevention and treatment of bone infections.