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Organ‐on‐a‐Chip: Patient‐Specific Organoid and Organ‐on‐a‐Chip: 3D Cell‐Culture Meets 3D Printing and Numerical Simulation (Adv. Biology 6/2021)
Author(s) -
Zheng Fuyin,
Xiao Yuminghao,
Liu Hui,
Fan Yubo,
Dao Ming
Publication year - 2021
Publication title -
advanced biology
Language(s) - English
Resource type - Journals
ISSN - 2701-0198
DOI - 10.1002/adbi.202170061
Subject(s) - organoid , organ on a chip , chip , organ culture , consistency (knowledge bases) , computer science , 3d cell culture , cell culture , computational biology , nanotechnology , biology , microbiology and biotechnology , in vitro , materials science , artificial intelligence , microfluidics , telecommunications , biochemistry , genetics
In article number 2000024, Fuyin Zheng, Yubo Fan, Ming Dao, and co‐workers show that organoids and organ‐on‐a‐chip are synergistic engineering approaches linking with vascularization and innervation to faithfully reconstitute in vitro organ‐level structures and functions with high structural fidelity, cellular consistency, environmental control ability, integration as well as through‐put. This review also detail current achievements, barriers, and future prospects of these promising combinations by incorporating organoids, organ‐a‐on‐chip, 3D printing, and numerical simulation toward patient‐specific disease‐on‐a‐chip and human‐on‐a‐chip.