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Antibody‐Antigen Interactions: Design of Smart Antibody Mimetics with Photosensitive Switches (Adv. Biology 5/2021)
Author(s) -
He Lian,
Tan Peng,
Huang Yun,
Zhou Yubin
Publication year - 2021
Publication title -
advanced biology
Language(s) - English
Resource type - Journals
ISSN - 2701-0198
DOI - 10.1002/adbi.202170053
Subject(s) - crispr , antibody , optogenetics , antigen , modular design , biology , microbiology and biotechnology , computational biology , computer science , genetics , neuroscience , gene , operating system
In article number 2000541, Yubin Zhou, Yun Huang, and co‐workers developed innovative optogenetic tools to control antibody‐antigen interactions, named Sunbody and Moonbody after the Chinese mythological figures Hou Yi the Sun‐shooter and Chang'e the Lady in the Moon, respectively. These photoswitchable modular antibody‐like scaffolds contain three allosterically sensitive complementarity‐determining regions (symbolized by three rabbits on the moon and three flares on the sun surface), which enable optical control of protein degradation, protein delocalization, immunogenic cell death, transcriptional programming, and CRISPR‐aided base editing.