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Coronavirus Antigens: Efficient Human Cell Coexpression System and Its Application to the Production of Multiple Coronavirus Antigens (Adv. Biology 4/2021)
Author(s) -
Kim Chonsaeng,
Jeong You Kyeong,
Yu Jihyeon,
Shin Hye Jin,
Ku Keun Bon,
Cha Hyung Jin,
Han Jun Hee,
Hong SungAh,
Kim BumTae,
Kim SeongJun,
Woo JaeSung,
Bae Sangsu
Publication year - 2021
Publication title -
advanced biology
Language(s) - English
Resource type - Journals
ISSN - 2701-0198
DOI - 10.1002/adbi.202170041
Subject(s) - antigen , virology , biology , immunology
The production of biomolecules that require human‐specific lipid environments is extremely useful for basic research and medical applications. In article number 2000154, Seong‐Jun Kim, Jae‐Sung Woo, Sangsu Bae, and co‐workers integrate multiple proteins or virus antigens into defined transcriptional hotspots in the human genome via a homology‐independent targeted insertion method using CRISPR nucleases. This system is similar to a production pipeline of biomolecules in a factory controlled by CRISPR.