Premium
Mechanical Stress Modulation: Modulation of Mechanical Stress Mitigates Anti‐Dsg3 Antibody‐Induced Dissociation of Cell–Cell Adhesion (Adv. Biology 1/2021)
Author(s) -
Jin Xiaowei,
Rosenbohm Jordan,
Kim Eunju,
Esfahani Amir Monemian,
SeiffertSinha Kristina,
Wahl James K.,
Lim Jung Yul,
Sinha Animesh A.,
Yang Ruiguo
Publication year - 2021
Publication title -
advanced biology
Language(s) - English
Resource type - Journals
ISSN - 2701-0198
DOI - 10.1002/adbi.202170014
Subject(s) - antibody , cell , cell adhesion , microbiology and biotechnology , dissociation (chemistry) , desmoglein 3 , biophysics , pemphigus vulgaris , chemistry , immunology , autoantibody , biology , biochemistry
In article number 2000159, Ruiguo Yang and co‐workers report a protective mechanism of external mechanical stress that mitigates cell–cell dissociation induced by anti‐Dsg3 antibodies, similar to the effect of autoantibodies in patients with pemphigus vulgaris. The external cyclic stretch suppresses anti‐Dsg3 antibody‐activated pathways and enhances cell–cell adhesion.