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Phagosomal pH Regulation: Revealing the Phagosomal pH Regulation and Inflammation of Macrophages after Endocytosing Polyurethane Nanoparticles by A Ratiometric pH Nanosensor (Adv. Biology 1/2021)
Author(s) -
Wong ChuiWei,
Pratiwi Feby Wijaya,
Chen Peilin,
Mou ChungYuan,
Hsu Shanhui
Publication year - 2021
Publication title -
advanced biology
Language(s) - English
Resource type - Journals
ISSN - 2701-0198
DOI - 10.1002/adbi.202170013
Subject(s) - polyurethane , nanoparticle , nanosensor , mesoporous silica , chemistry , intracellular , inflammation , biophysics , nanotechnology , mesoporous material , materials science , chemical engineering , nuclear chemistry , biochemistry , biology , immunology , catalysis , organic chemistry , engineering
In article number 2000200, Chung‐Yuan Mou, Shan‐hui Hsu, and co‐workers develop a pH nanosensor made of mesoporous silica nanoparticles (NPs) and coated with biodegradable polyurethane (PU) to reveal the intracellular journey of the PU NPs. The alkalinization process of the activated macrophages is delayed after taking up PU NPs, which leads to late endosomelysosome fusion and causes a weak immune response against the biodegradable PU.