Premium
Mitochondria in Neuronal Health: From Energy Metabolism to Parkinson's Disease
Author(s) -
Murali Mahadevan Hariharan,
Hashemiaghdam Arsalan,
Ashrafi Ghazaleh,
Harbauer Angelika Bettina
Publication year - 2021
Publication title -
advanced biology
Language(s) - English
Resource type - Journals
ISSN - 2701-0198
DOI - 10.1002/adbi.202100663
Subject(s) - mitochondrion , bioenergetics , parkinson's disease , neuroscience , anabolism , energy metabolism , disease , biology , premovement neuronal activity , neurotransmission , adenosine triphosphate , mitophagy , metabolism , microbiology and biotechnology , medicine , endocrinology , biochemistry , autophagy , apoptosis , receptor
Mitochondria are the main suppliers of neuronal adenosine triphosphate and play a critical role in brain energy metabolism. Mitochondria also serve as Ca 2+ sinks and anabolic factories and are therefore essential for neuronal function and survival. Dysregulation of neuronal bioenergetics is increasingly implicated in neurodegenerative disorders, particularly Parkinson's disease. This review describes the role of mitochondria in energy metabolism under resting conditions and during synaptic transmission, and presents evidence for the contribution of neuronal mitochondrial dysfunction to Parkinson's disease.