Open AccessPlasmon‐Enhanced Biosensing: Plasmon‐Enhanced Biosensing for Multiplexed Profiling of Extracellular Vesicles (Adv. Biosys. 12/2020)
Author(s) -
Min Jouha,
Son Taehwang,
Hong JaeSang,
Cheah Pike See,
Wegemann Andreas,
Murlidharan Koushik,
Weissleder Ralph,
Lee Hakho,
Im Hyungsoon
Publication year - 2020
Publication title -
advanced biosystems
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.153
H-Index - 18
ISSN - 2366-7478
DOI - 10.1002/adbi.202070123
Subject(s) - surface plasmon resonance , biosensor , plasmon , extracellular vesicles , fluorescence , vesicle , nanotechnology , conjugated system , materials science , colloidal gold , surface plasmon , biophysics , chemistry , nanoparticle , optoelectronics , optics , microbiology and biotechnology , biology , membrane , biochemistry , polymer , physics , composite material
In article number 23, Hyungsoon Im and co‐workers label extracellular vesicles, which are nanoscale phospholipid vesicles secreted by cells, with fluorescently conjugated antibodies. The fluorescence signals are amplified by periodic gold nanohole structures based on surface plasmon resonance. Multi‐fluorescence imaging enables multiplexed analyses of proteins with improved sensitivities.