Open Access3D Neural Spheroids: Surface‐Functionalized Self‐Standing Microdevices Exhibit Predictive Localization and Seamless Integration in 3D Neural Spheroids (Adv. Biosys. 11/2020)
Author(s) -
Lecomte Aziliz,
Giantomasi Lidia,
Rancati Silvia,
Boi Fabio,
Angotzi Gian Nicola,
Berdondini Luca
Publication year - 2020
Publication title -
advanced biosystems
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.153
H-Index - 18
ISSN - 2366-7478
DOI - 10.1002/adbi.202070113
Subject(s) - spheroid , actuator , silicon , nanotechnology , surface (topology) , neural engineering , biomimetic materials , materials science , computer science , biomedical engineering , biological system , engineering , chemistry , artificial intelligence , optoelectronics , biology , mathematics , biochemistry , geometry , in vitro
In article number 2000114, Luca Berdondini and co‐workers present 3D neurospheroids with self‐standing silicon microdevices internalized at different levels. Results are obtained by uncovering the control capability of silicon surface engineering to drive microdevices at predefined sites during cellular aggregation and 3D growth. This work paves the way to bionic brain‐tissue models with inbuilt untethered bioelectronic sensors and actuators.