Open AccessTissue Engineering: Reconfigurable Microphysiological Systems for Modeling Innervation and Multitissue Interactions (Adv. Biosys. 9/2020)
Author(s) -
Soucy Jonathan R.,
Bindas Adam J.,
Brady Ryan,
Torregrosa Tess,
Decourt Cailey M.,
Hosic Sanjin,
Dai Guohao,
Koppes Abigail N.,
Koppes Ryan A.
Publication year - 2020
Publication title -
advanced biosystems
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.153
H-Index - 18
ISSN - 2366-7478
DOI - 10.1002/adbi.202070091
Subject(s) - microfluidics , exploit , nanotechnology , computer science , meniscus , materials science , physics , computer security , incidence (geometry) , optics
To overcome the limitations of traditional organ chips, in article number 2000133, Ryan A. Koppes and co‐workers have implemented a “cut and assemble” manufacturing technique to exploit the meniscus pinning effect, via GelPins, to constrain 3D biomaterials. These GelPins enable the formation of discrete, yet contiguous hydrogel structures in both x‐y and z planes within custom microfluidic devices, facilitating future investigation of innervation and heterogenous tissue interactions.