Open AccessBreast Cancer Dormancy: Understanding ER+ Breast Cancer Dormancy Using Bioinspired Synthetic Matrices for Long‐Term 3D Culture and Insights into Late Recurrence (Adv. Biosys. 9/2020)
Author(s) -
Ovadia Elisa M.,
Pradhan Lina,
Sawicki Lisa A.,
Cowart Julie E.,
Huber Rebecca E.,
Polson Shawn W.,
Chen Chuming,
Golen Kenneth L.,
Ross Karen E.,
Wu Cathy H.,
Kloxin April M.
Publication year - 2020
Publication title -
advanced biosystems
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.153
H-Index - 18
ISSN - 2366-7478
DOI - 10.1002/adbi.202070090
Subject(s) - dormancy , breast cancer , autophagy , cancer , oncology , cancer research , human breast , medicine , biology , apoptosis , botany , biochemistry , germination
In article number 2000119, April M. Kloxin and co‐workers establish a 3D human breast cancer dormancy model that captures key biophysical and biochemical properties of common metastatic microenvironments for late recurrence. The studies with this model demonstrate how matrix density and cell type impact cell dormancy versus proliferation and suggests autophagy as a survival mechanism of dormant ER+ breast cancer cells.