Open AccessAntischistosomal Drugs: Parallelized Impedance‐Based Platform for Continuous Dose‐Response Characterization of Antischistosomal Drugs (Adv. Biosys. 7/2020)
Author(s) -
Ravaynia Paolo S.,
Lombardo Flavio C.,
Biendl Stefan,
Dupuch Matthias A.,
Keiser Jennifer,
Hierlemann Andreas,
Modena Mario M.
Publication year - 2020
Publication title -
advanced biosystems
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.153
H-Index - 18
ISSN - 2366-7478
DOI - 10.1002/adbi.202070073
Subject(s) - pharmacology , drug , computer science , chemistry , medicine
In article number 1900304, Paolo S. Ravaynia, Jennifer Keiser, and co‐workers show a parallelized impedance‐based platform with integrated electrodes for the detection of the viability of S. mansoni larvae exposed to test compounds. This unbiased and label‐free technique enables to quantitatively score in parallel the responses of the parasites to multiple drug conditions, and allows for long‐term and continuous assessment of in‐vitro antischistosomal drug efficacy. Illustration credits: Paolo S. Ravaynia and Susanna J. Zamolo.