Open AccessNeural Networks: Alginate Sulfate Substrates Control Growth Factor Binding and Growth of Primary Neurons: Toward Engineered 3D Neural Networks (Adv. Biosys. 7/2020)
Author(s) -
Kfoury Georges,
El Habbaki Vanessa,
Malaeb Waddah,
Weaver Sean,
Momotenko Dmitry,
Mhanna Rami
Publication year - 2020
Publication title -
advanced biosystems
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.153
H-Index - 18
ISSN - 2366-7478
DOI - 10.1002/adbi.202070072
Subject(s) - sulfation , nerve growth factor , fibroblast growth factor , primary (astronomy) , growth factor , artificial neural network , chemistry , neural tube , glycosaminoglycan , biophysics , materials science , microbiology and biotechnology , biology , computer science , biochemistry , embryo , artificial intelligence , receptor , physics , astronomy
In article number 2000047, Rami Mhanna and co‐workers show that tuning the degree of sulfation and concentration of glycosaminoglycan mimetic alginate sulfates enables controlled binding of basic fibroblast growth factor and nerve growth factor. Sulfated alginates are used to construct substrates with controlled growth factor loading for prolonged primary neural cell outgrowth in two and three dimensions, and to bioprint 3D neural networks using pressure‐driven deposition through micropipette nozzles.