Open AccessAdipose Tissue Pathology: Collagen Stiffness and Architecture Regulate Fibrotic Gene Expression in Engineered Adipose Tissue (Adv. Biosys. 6/2020)
Author(s) -
Di Caprio Nikolas,
Bellas Evangelia
Publication year - 2020
Publication title -
advanced biosystems
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.153
H-Index - 18
ISSN - 2366-7478
DOI - 10.1002/adbi.202070061
Subject(s) - adipose tissue , fibrosis , adipocyte , microbiology and biotechnology , adipose tissue macrophages , pathology , biology , endocrinology , medicine , white adipose tissue
In article number 1900286, Evangelia Bellas and Nikolas Di Caprio show that adipocytes are mechanically sensitive to microenvironment changes. When exposed to increased mechanical cues via enhanced crosslinking, adipocytes initiate a biochemical cascade through actin contractility, leading to dysfunctional pro‐fibrotic outcomes. The results indicate the microenvironment plays an essential role in adipocyte dysfunction during the progression of obesity and adipose tissue fibrosis.