Open AccessCell Micropatterning: Self‐Organization of Fibroblast‐Laden 3D Collagen Microstructures from Inkjet‐Printed Cell Patterns (Adv. Biosys. 5/2020)
Author(s) -
Park Ju An,
Lee HwaRim,
Park SeungYeol,
Jung Sungjune
Publication year - 2020
Publication title -
advanced biosystems
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.153
H-Index - 18
ISSN - 2366-7478
DOI - 10.1002/adbi.202070054
Subject(s) - micropatterning , fibroblast , microstructure , extracellular matrix , cell , nanotechnology , materials science , matrix (chemical analysis) , microbiology and biotechnology , chemistry , biophysics , composite material , biology , in vitro , biochemistry
In article number 1900280, Hwa‐Rim Lee, Sungjune Jung, Ju An Park, and Seung‐Yeol Park fabricate 3D collagen microstructures by 2D inkjet‐printing of living cells in predestined designs. The patterns of fibroblasts printed on a collagen bed with controlled population density induce cell‐to‐extracellular matrix interaction between the cells and the surrounding collagen, which leads to self‐organization of the 3D microstructures. This method provides a simple and powerful way to recapitulate the fine shape and microstructures of native tissues in 3D.