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Modulating Flow Topology in Microdroplets to Control Reaction Kinetics
Author(s) -
Ma Shaohua,
Zhao Haoran,
Galan Edgar A.,
Balabani Stavroula
Publication year - 2021
Publication title -
advanced biology
Language(s) - English
Resource type - Journals
ISSN - 2701-0198
DOI - 10.1002/adbi.202000309
Subject(s) - microfluidics , kinetics , laboratory flask , macromolecule , chemical kinetics , mixing (physics) , flow (mathematics) , chemistry , reaction rate , microreactor , chemical physics , nanotechnology , materials science , topology (electrical circuits) , biological system , mechanics , physics , catalysis , organic chemistry , biology , classical mechanics , engineering , biochemistry , quantum mechanics , electrical engineering
In traditional reaction flasks, the reaction rate of macromolecular compounds is dictated by the concentrations and distribution of reactants along with their intrinsic reaction kinetics. Controlling reaction kinetics in microfluidic droplets has been proposed through the regulation of flow dynamics, but is yet to be demonstrated experimentally. Here, this hypothesis is verified by accelerating or suppressing macromolecular reactant mixing in microfluidic droplets. The control of reaction kinetics through the modulation of flow topology in microdroplets may enable further developments in modeling macromolecular systems.