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Injectable Mesenchymal Stem Cell‐Laden Matrigel Microspheres for Endometrium Repair and Regeneration
Author(s) -
Xu Bing,
Cao Yuanxiong,
Zheng Zheng,
Galan Edgar A.,
Hu Zhiwei,
Ge Jun,
Xing Xinhui,
Ma Shaohua
Publication year - 2021
Publication title -
advanced biology
Language(s) - English
Resource type - Journals
ISSN - 2701-0198
DOI - 10.1002/adbi.202000202
Subject(s) - mesenchymal stem cell , matrigel , endometrium , regeneration (biology) , transplantation , stem cell , medicine , andrology , surgery , biology , pathology , angiogenesis , microbiology and biotechnology
Endometrial injury and intrauterine adhesions are increasingly reported in recent years; however, treatment options remain limited. Intravenous injection of mesenchymal stem cells (MSCs) for endometrium regeneration has limited effectiveness as the retention rate of transplanted cells is low. Hydrogel‐based tissue‐engineered solutions, such as MSC‐seeded bioscaffolds, are reported to increase retention rates; however, a less invasive alternative is still desirable. 560‐µm homogeneous Matrigel microspheres are fabricated, loading them with about 1500 MSCs and injecting them into the injured endometria of rats’ uteri. This minimally invasive procedure is proved to significantly increase endometrium thickness by over onefold after 21 d ( p < 0.0001) and fertility rates from 25% to 75% in impaired and repaired uteri ( p < 0.001), respectively. This study provides a minimally invasive alternative to endometrium repair with the promise to establish a broad‐spectrum technique for MSC transplantation.