Open AccessTissue Engineering: Senescent Cells with Augmented Cytokine Production for Microvascular Bioengineering and Tissue Repairs (Adv. Biosys. 8/2019)
Author(s) -
Xiao Yang,
Liu Chang,
Chen Zhuo,
Blatchley Michael R.,
Kim Dongjoo,
Zhou Jing,
Xu Ming,
Gerecht Sharon,
Fan Rong
Publication year - 2019
Publication title -
advanced biosystems
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.153
H-Index - 18
ISSN - 2366-7478
DOI - 10.1002/adbi.201970082
Subject(s) - paracrine signalling , tissue engineering , cytokine , microbiology and biotechnology , secretion , fibroblast , basic fibroblast growth factor , immunology , biology , growth factor , medicine , biomedical engineering , cell culture , endocrinology , receptor , genetics
In article number 1900089, Rong Fan and co‐workers demonstrate the use of senescent fibroblast cells as a living source for proangiogenic factor secretion. Due to its senescent state, these cells do not proliferate to jeopardize the original design of neotissue architecture but only accelerate tissue microvascularization via paracrine signaling.