Open AccessBoron Ions: Simultaneous Boron Ion‐Channel/Growth Factor Receptor Activation for Enhanced Vascularization (Adv. Biosys. 1/2019)
Author(s) -
Rico Patricia,
RodrigoNavarro Aleixandre,
de la Peña Marcos,
Moulisová Vladimira,
Costell Mercedes,
SalmerónSánchez Manuel
Publication year - 2019
Publication title -
advanced biosystems
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.153
H-Index - 18
ISSN - 2366-7478
DOI - 10.1002/adbi.201970014
Subject(s) - boron , intracellular , transmembrane protein , biophysics , ion channel , chemistry , receptor , microbiology and biotechnology , ion , ligand (biochemistry) , growth factor , biology , biochemistry , organic chemistry
Active NaBC1 physically co‐localizes with other transmembrane proteins, such as active VEGFR, leading to simultaneous enhanced intracellular signaling in the presence of ultra‐low doses of ligand (simulating physiological levels). To fully potentiate the ability of biomaterials to control vascularization mechanisms, full attention needs to be given to the interplay between specific cell membrane receptors in order to mimic biological niches at the molecular level. In article number 1800220 , Patricia Rico, Manuel Salmerón‐Sánchez, and co‐workers present a new therapeutic strategy for vascularization using ions instead of growth factors.