Open AccessParticulate Vaccines: Design of Bacterial Inclusion Bodies as Antigen Carrier Systems (Adv. Biosys. 11/2018)
Author(s) -
Chen Shuxiong,
Sandford Sarah,
Kirman Joanna,
Rehm Bernd H. A.
Publication year - 2018
Publication title -
advanced biosystems
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.153
H-Index - 18
ISSN - 2366-7478
DOI - 10.1002/adbi.201870103
Subject(s) - antigen , escherichia coli , immune system , immunity , immunology , microbiology and biotechnology , biology , chemistry , biochemistry , gene
In article number 1800118 , Bernd H. A. Rehm and co‐workers show how bioengineering of mycobacterial antigens enhances their intermolecular interactions that mediate self‐assembly of discrete antigen particles, inside a safe bacterial cell factory, Escherichia coli . The resulting pure antigen particles induce strong antigen‐specific humoral and cell‐mediated immune responses. This innovative bioengineering approach enables rapid development of custom‐made particulate vaccines with augmented immunological properties toward induction of protective immunity.