Open AccessProtein Micropatterns: Multiphoton 3D Microprinting of Protein Micropatterns with Spatially Controlled Heterogeneity – A Platform for Single Cell Matrix Niche Studies (Adv. Biosys. 8/2018)
Author(s) -
Huang Nan,
Li Chuen Wai,
Chan Barbara Pui
Publication year - 2018
Publication title -
advanced biosystems
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.153
H-Index - 18
ISSN - 2366-7478
DOI - 10.1002/adbi.201870072
Subject(s) - niche , extracellular matrix , scaffold , mesenchymal stem cell , matrix (chemical analysis) , nanotechnology , microbiology and biotechnology , cell , stem cell niche , chemistry , biophysics , materials science , stem cell , biology , biochemistry , biomedical engineering , progenitor cell , engineering , chromatography
A cell niche is a complex microenvironment that cells are exposed to in tissues. In article number 1800053 , Barbara Pui Chan and co‐workers use multiphoton micro‐printing technology to create protein micro‐patterns with independently and spatially controlled matrix and mechanical properties. Human mesenchymal stem cells cultured on a protein micro‐niche spread towards selective protein islands with different extracellular matrices. This platform contributes to highthroughput screening of cell niche factors for biomimetic scaffold design.