Open AccessBiomimetics: Sulfated Alginate as a Mimic of Sulfated Glycosaminoglycans: Binding of Growth Factors and Effect on Stem Cell Behavior (Adv. Biosys. 7/2017)
Author(s) -
Mhanna Rami,
Becher Jana,
Schnabelrauch Matthias,
Reis Rui L.,
Pashkuleva Iva
Publication year - 2017
Publication title -
advanced biosystems
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.153
H-Index - 18
ISSN - 2366-7478
DOI - 10.1002/adbi.201770049
Subject(s) - sulfation , glycosaminoglycan , biomimetics , tissue engineering , chemistry , nanotechnology , stem cell , biophysics , materials science , microbiology and biotechnology , biomedical engineering , biochemistry , biology , engineering
Increased sulfation of biomaterials such as alginate increases binding of growth factors, mimicking the effect of natural sulfated glycosaminoglycans. In article number 1700043 , Rami Mhanna, Iva Pashkuleva, and co‐workers demonstrate that incorporating these sulfated materials in engineered layer‐by‐layer structures enables precise control of growth factor adsorption and subsequent stem cell fate. Alginate sulfatebased films and scaffolds can be further used for mechanistic basic science and applied tissue engineering investigations. The authors thank Diana El Hajj for preparing the cover image.