Open AccessElectrical Imaging: Investigating Cellular Function at High Resolution
Author(s) -
Zeck Günther,
Jetter Florian,
Channappa Lakshmi,
Bertotti Gabriel,
Thewes Roland
Publication year - 2017
Publication title -
advanced biosystems
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.153
H-Index - 18
ISSN - 2366-7478
DOI - 10.1002/adbi.201700107
Subject(s) - millisecond , neuroscience , extracellular , function (biology) , scale (ratio) , nerve cells , electrophysiology , computer science , physics , nanotechnology , materials science , chemistry , biology , biochemistry , quantum mechanics , astronomy , evolutionary biology , microbiology and biotechnology
Electrical imaging of extracellular potentials reveals the activity of electrogenic cells and of networks thereof over several orders of magnitude, both in space and time. On a spatial scale, electrical activity propagates in nanometer‐sized nerve fibers (axons, dendrites), which connect cells in a biological network over several millimeters. On a temporal scale, changes of the extracellular potential caused by action potentials occur on a sub‐millisecond scale, while network activity may be modulated over seconds. Here, different electrode arrays are described, which are designed to image modulations of the electrical potentials over a wide spatiotemporal range. In the second part, typical applications and scientific questions in neuroscience research addressed so far are reviewed. The review ends with an outlook on expected developments.