Premium
A semi‐adaptive control approach to closed‐loop medication infusion
Author(s) -
Jin Xin,
Kim ChangSei,
Dumont Guy A.,
Ansermino J. Mark,
Hahn JinOh
Publication year - 2017
Publication title -
international journal of adaptive control and signal processing
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 66
eISSN - 1099-1115
pISSN - 0890-6327
DOI - 10.1002/acs.2696
Subject(s) - control theory (sociology) , controller (irrigation) , adaptive control , sensitivity (control systems) , fidelity , computer science , identification (biology) , closed loop , control engineering , reference model , system identification , set (abstract data type) , control (management) , engineering , data modeling , artificial intelligence , telecommunications , botany , software engineering , electronic engineering , database , agronomy , biology , programming language
Summary This paper presents a semi‐adaptive control approach to closed‐loop medication infusion problems. The rationale underlying this approach is to design a controller that can adapt model parameters with a large impact on the model's fidelity while fixing the remaining parameters at nominal values. In this paper, a control‐oriented model for this purpose is derived via system identification and sensitivity analysis of a low‐order model capturing the direct dose‐response relationship Using the model thus derived, a model‐reference adaptive controller and a composite adaptive controller are designed and compared with each other. In‐silico simulation results using remifentanil's effect on respiratory rate as an example indicate that both controllers can regulate the output at commanded set points. Copyright © 2016 John Wiley & Sons, Ltd.