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Robust control of depth of anesthesia
Author(s) -
Dumont Guy A.,
Martinez Arturo,
Ansermino J. Mark
Publication year - 2009
Publication title -
international journal of adaptive control and signal processing
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 66
eISSN - 1099-1115
pISSN - 0890-6327
DOI - 10.1002/acs.1087
Subject(s) - control theory (sociology) , robust control , propofol , pid controller , controller (irrigation) , set point , divergence (linguistics) , anesthesia , computer science , medicine , control engineering , control (management) , control system , engineering , artificial intelligence , temperature control , agronomy , linguistics , philosophy , electrical engineering , biology
This paper presents a systematic procedure to design both robust PID controllers and robust controllers based on fractional calculus (based on Commande Robuste d'Ordre Non Entier, or CRONE methodology) to regulate the hypnotic state of anesthesia with the intravenous administration of propofol. The objective of the controllers is to provide an adequate drug administration regimen for propofol to avoid under or over dosing of the patients. The controllers are designed to compensate for the patients inherent drug–response variability (uncertainty), to achieve good output disturbance rejection, and to attain good set point response. The performance of the controllers is assessed by calculating typical time domain measures and using the median PE, median absolute PE, divergence, and wobble. Copyright © 2008 John Wiley & Sons, Ltd.