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Objective  Examinations of Patient‐Reported Outcomes Measurement Information System ( PROMIS ) measures in adult systemic lupus erythematosus ( SLE ) have provided support for their cross‐sectional validity in  SLE . We estimated responsiveness to change, meaningful changes (minimally important differences [ MID s]), and the patient acceptable symptom state ( PASS ) for five  PROMIS  short forms to facilitate longitudinal use and interpretation of  PROMIS  scales in  SLE .    Methods  Data from five administrations of  PROMIS  short forms in the  FORWARD SLE  cohorts were used. Pearson correlation coefficients were used to assess associations between changes in  PROMIS  measures and changes in anchor measures for responsiveness analyses. Worse, same, or better groups were defined for each anchor. Differences in  PROMIS  scores were calculated for each consecutive  PROMIS  administration; mean changes in  PROMIS  scores of individuals in the worse, same, and better groups were calculated. Both anchor‐based and distribution‐based methods were used to estimate  MID s.  PASS  was defined as the 75th‐percentile positive score among those who considered their health to be acceptable or who were somewhat or very satisfied with their health.    Results  All  PROMIS  short forms showed adequate responsiveness to changes in related patient‐reported outcomes. However, only the fatigue and pain interference scales were responsive to self‐reported  SLE  activity. Taking into account all methods, we estimated  MID s for each scale to be approximately two points. All  PASS  values were better than the population mean T‐score of 50.    Conclusion  These results support use and further study of  PROMIS  short forms in  SLE  and should facilitate interpretation of  PROMIS  scores and changes.

acr open rheumatology

Estimates of Responsiveness, Minimally Important Differences, and Patient Acceptable Symptom State in Five Patient‐Reported Outcomes Measurement Information System Short Forms in Systemic Lupus Erythematosus