Premium
Accelerating Medicines Partnership: Organizational Structure and Preliminary Data From the Phase 1 Studies of Lupus Nephritis
Author(s) -
Hoover Paul,
Der Evan,
Berthier Celine C.,
Arazi Ar,
Lederer James A.,
James Judith A.,
Buyon Jill,
Petri Michelle,
Belmont H. Michael,
Izmirly Peter,
Wofsy David,
Hacohen Nir,
Diamond Betty,
Putterman Chaim,
Davidson Anne
Publication year - 2020
Publication title -
arthritis care and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.032
H-Index - 163
eISSN - 2151-4658
pISSN - 2151-464X
DOI - 10.1002/acr.24066
Subject(s) - lupus nephritis , general partnership , systemic lupus erythematosus , cohort , disease , phase (matter) , medicine , knowledge management , intensive care medicine , data science , business , computer science , chemistry , finance , organic chemistry
The Accelerating Medicines Partnership ( AMP ) Lupus Network was established as a partnership between the National Institutes of Health, pharmaceutical companies, nonprofit stakeholders, and lupus investigators across multiple academic centers to apply high‐throughput technologies to the analysis of renal tissue, urine, and blood from patients with lupus nephritis ( LN ). The AMP network provides publicly accessible data to the community with the goal of generating new scientific hypotheses and improving diagnostic and therapeutic tools so as to improve disease outcomes. We present here a description of the structure of the AMP Lupus Network and a summary of the preliminary results from the phase 1 studies. The successful completion of phase 1 sets the stage for analysis of a large cohort of LN samples in phase 2 and provides a model for establishing similar discovery cohorts.