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Better Health‐Related Quality of Life in Systemic Lupus Erythematosus Predicted by Low Disease Activity State/Remission: Data From the Peruvian Almenara Lupus Cohort
Author(s) -
UgarteGil Manuel F.,
GamboaCárdenas Rocío V.,
ReáteguiSokolova Cristina,
MedinaChinchón Mariela,
Zevallos Francisco,
EleraFitzcarrald Claudia,
PimentelQuiroz Victor,
CuchoVenegas Jorge M.,
RodríguezBellido Zoila,
PastorAsurza César A.,
Alarcón Graciela S.,
PerichCampos Risto
Publication year - 2020
Publication title -
arthritis care and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.032
H-Index - 163
eISSN - 2151-4658
pISSN - 2151-464X
DOI - 10.1002/acr.24009
Subject(s) - medicine , prednisone , systemic lupus erythematosus , confidence interval , quality of life (healthcare) , confounding , cohort , disease , nursing
Objective To determine if low disease activity state ( LDAS )/remission predicts a better health‐related quality of life ( HRQ oL). Methods Patients with systemic lupus erythematosus from a single center and having completed at least 2 visits were included. Visits were performed every 6 months. HRQ oL was measured with the LupusQoL questionnaire. The definition of remission included a Systemic Lupus Erythematosus Disease Activity Index 2000 ( SLEDAI ‐2K) score of 0, prednisone daily dosage of ≤5 mg/day, and immunosuppressive drugs on maintenance dose. LDAS was defined as a SLEDAI ‐2K score of ≤4, prednisone daily dosage of ≤7.5 mg/day, and immunosuppressive drugs as maintenance therapy. For these analyses, remission and LDAS were combined as one variable. Generalized estimating equations were calculated, using as the outcome 1 of each of the 8 components of the LupusQoL questionnaire in the subsequent visit and the activity state in the previous visit. Multivariable models were adjusted for possible confounders. Results A total of 243 patients were included. During the follow‐up, 590 visits (61.6%) were categorized as LDAS /remission. LDAS /remission predicted a better HRQ oL in the components of physical health (B = 4.17 [95% confidence interval (95% CI ) 1.20, 7.14]; P = 0.006), pain (B = 6.47 [95% CI 3.18, 9.76]; P < 0.001), planning (B = 4.97 [95% CI 1.43, 8.52]; P = 0.006), burden to others (B = 4.12 [95% CI 0.24, 8.01]; P = 0.037], emotional health (B = 4.50 [95% CI 1.56, 7.44]; P = 0.003), and fatigue (B = 3.25 [95% CI 0.04, 6.47]; P = 0.048). Conclusion Being in LDAS /remission predicts a better HRQ oL, especially in the components of physical health, pain, planning, burden to others, emotional health, and fatigue.