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Different Phenotypes of Osteoarthritis in the Lumbar Spine Reflected by Demographic and Clinical Characteristics: The Johnston County Osteoarthritis Project
Author(s) -
Goode Adam P.,
Cleveland Rebecca J.,
George Steven Z.,
Kraus Virginia B.,
Schwartz Todd A.,
Gracely Richard H.,
Jordan Joanne M.,
Golightly Yvonne M.
Publication year - 2020
Publication title -
arthritis care and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.032
H-Index - 163
eISSN - 2151-4658
pISSN - 2151-464X
DOI - 10.1002/acr.23918
Subject(s) - medicine , osteoarthritis , facet joint , facet (psychology) , body mass index , physical therapy , confidence interval , odds ratio , lumbar , surgery , psychology , pathology , social psychology , alternative medicine , personality , big five personality traits
Objective To determine if associations between demographic and clinical characteristics and appendicular joint osteoarthritis ( OA ) reflect different phenotypes of OA in the lumbar spine. Methods Participants were from the Johnston County OA Project. Demographic information consisted of age, sex, and race (white and African American), and clinical characteristics consisted of body mass index ( BMI ), low back pain and injury, and knee, hip, and hand OA . Participants were categorized as having spine OA , facet joint OA , both spine OA and facet joint OA , or neither spine OA nor facet joint OA (referent group). Multinomial regression models were used to determine odds ratios ( OR s) and 95% confidence intervals (95% CI s). Results Of 1,793 participants, the mean ± SD age was 66.2 ± 10.1 years, and the mean ± SD BMI was 30.7 ± 6.2. The majority of the participants were women (n = 1,144 [63.8%]), and 31.8% of the participants (n = 570) were African American. Eighteen percent of participants had neither spine OA nor facet joint OA , 22.8% had facet joint OA , 13.2% had spine OA , and 46.0% had both spine OA and facet joint OA . In adjusted analyses, African Americans were less likely to have facet joint OA ( OR 0.68 [95% CI 0.49–0.95]) or both spine OA and facet joint OA ( OR 0.51 [95% CI 0.37–0.70]). Women were more likely to have facet joint OA ( OR 1.71 [95% CI 1.24–2.36]). Having a BMI of ≥30 was associated with having facet joint OA ( OR 1.76 [95% CI 1.28–2.42]) and both spine OA and facet joint OA ( OR 1.85 [95% CI 1.37–2.51]). Knee OA was associated with all 3 OA groups, while lower back injury was associated only with those with spine OA . Participants with hip OA were less likely to have facet joint OA . Conclusion Race, sex, BMI , hip OA , and lower back injury may help identify different OA phenotypes in the lumbar spine.