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Relationships Between Adverse Childhood Experiences and Health Status in Systemic Lupus Erythematosus
Author(s) -
DeQuattro Kimberly,
Trupin Laura,
Li Jing,
Katz Patricia P.,
Murphy Louise B.,
Yelin Edward H.,
Rush Stephanie,
Lanata Cristina,
Criswell Lindsey A.,
Dall'Era Maria,
Yazdany Jinoos
Publication year - 2020
Publication title -
arthritis care and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.032
H-Index - 163
eISSN - 2151-4658
pISSN - 2151-464X
DOI - 10.1002/acr.23878
Subject(s) - medicine , behavioral risk factor surveillance system , systemic lupus erythematosus , adverse childhood experiences , lupus nephritis , epidemiology , population , neglect , ethnic group , depression (economics) , demography , immunology , gerontology , disease , psychiatry , environmental health , mental health , sociology , anthropology , economics , macroeconomics
Objective Adverse childhood experiences ( ACE s) are associated with poor adult health and immune dysregulation. The impact of ACE s on patients with autoimmune disease is unknown. The present study was undertaken to compare the prevalence of ACE s in patients with systemic lupus erythematosus ( SLE ) to a population‐based survey estimate and to investigate relationships between ACE s and SLE outcomes. Methods Data derived from the California Lupus Epidemiology Study ( CLUES ), a sample of adult patients with SLE . Participants completed a 10‐item ACE questionnaire covering 3 domains (abuse, neglect, household challenges). We estimated ACE prevalence in 269 CLUES participants compared to geographically matched respondents from the 2015 California Behavioral Risk Factor Surveillance System ( BRFSS ), which was standardized to CLUES participant characteristics (age, sex, race/ethnicity). We examined associations of patient‐reported and physician‐assessed health status measures with overall ACE levels and domains using multivariable linear regression, controlling for sociodemographics, nephritis, and juvenile‐onset SLE . Results Although specific domains varied, overall ACE levels were similar for CLUES and BRFSS respondents. Among SLE patients, 63.2% had ≥1 ACE , and 19.3% had ≥4. ACE s were more prevalent in those who were older, women, Latino or African American, and without college degrees, but not in those with lupus nephritis. In adjusted models, higher ACE levels and ACE domains were associated with worse patient‐reported SLE activity, depression, and health status but were not significantly associated with physician‐assessed SLE activity, damage, or severity. Conclusion Given the association between ACE levels and important patient‐reported outcomes in SLE , our study reinforces the need for prevention of ACE s in childhood and for clinical interventions to promote resilience among adults who have experienced ACE s.