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Physical Activity and Worsening of Radiographic Findings in Persons With or at Higher Risk of Knee Osteoarthritis
Author(s) -
Jayabalan Prakash,
Kocherginsky Masha,
Chang Alison H.,
Rouleau Gerald W.,
Koloms Kimberly L.,
Lee Jungwha,
Dunlop Dorothy,
Chang Rowland W.,
Sharma Leena
Publication year - 2019
Publication title -
arthritis care and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.032
H-Index - 163
eISSN - 2151-4658
pISSN - 2151-464X
DOI - 10.1002/acr.23756
Subject(s) - medicine , osteoarthritis , confidence interval , odds ratio , body mass index , physical therapy , logistic regression , physical activity , population , knee pain , alternative medicine , environmental health , pathology
Objective The benefits of physical activity among persons with or at higher risk for knee osteoarthritis are well established. However, activity levels in this population are low, in part due to concern that activity will damage the knee joint. We hypothesized that sedentary and moderate‐vigorous physical activity are each associated with greater risk of radiographic worsening of knee OA . Methods In Osteoarthritis Initiative participants with or at higher risk for knee OA enrolled in an accelerometer substudy at 48 months (study baseline), physical activity was measured by a uniaxial accelerometer (ActiGraph GT 1M). Radiographic progression was defined as any 48 month to 96 month worsening of Kellgren/Lawrence (K/L) grade scores. All analyses were knee‐level; we used multivariable logistic regression with generalized estimating equations, adjusting for key covariates. Results Of the 1,206 participants, 631 (52%) were female, the mean ± SD age was 64 ± 9 years, and mean ± SD body mass index ( BMI ) was 28 ± 5. The mean ± SD average daily sedentary activity was 602 ± 86 minutes, average daily light activity was 284 ± 75 minutes, and average daily moderate‐vigorous activity was 20 ± 20 minutes. In 1,978 knees, 267 (14%) had worsening of K/L grade scores. In the multivariable model, age, sex, BMI , and pain, were associated with K/L grade worsening, but neither sedentary activity (adjusted odds ratio [ OR ] 0.99 [95% confidence interval (95% CI ) 0.97–1.01]) nor moderate‐vigorous activity (adjusted OR 1.00 [95% CI 0.91–1.09]) were associated with K/L grade worsening. Conclusion In persons with or at higher risk for knee OA , age, sex, BMI , and pain, but not objectively measured average daily minutes of sedentary or moderate‐vigorous activity, were associated with subsequent worsening of K/L grade. Whether findings differ in persons with more severe knee OA and/or engaged more frequently in moderate‐vigorous activity should be examined in future studies.