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Relationship Between Fish Consumption and Disease Activity in Rheumatoid Arthritis
Author(s) -
Tedeschi Sara K.,
Bathon Joan M.,
Giles Jon T.,
Lin TzuChieh,
Yoshida Kazuki,
Solomon Daniel H.
Publication year - 2018
Publication title -
arthritis care and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.032
H-Index - 163
eISSN - 2151-4658
pISSN - 2151-464X
DOI - 10.1002/acr.23295
Subject(s) - medicine , rheumatoid arthritis , interquartile range , cohort , confidence interval , subclinical infection , linear regression , fish consumption , fish <actinopterygii> , biology , fishery , machine learning , computer science
Objective To assess whether more frequent fish consumption is associated with lower rheumatoid arthritis ( RA ) disease activity scores among participants in an RA cohort. Methods We conducted a cross‐sectional analysis using baseline data from participants in the Evaluation of Subclinical Cardiovascular Disease and Predictors of Events in Rheumatoid Arthritis cohort study. Frequency of fish consumption was assessed by a baseline food frequency questionnaire assessing usual diet in the past year. Multivariable, total energy–adjusted linear regression models provided effect estimates and 95% confidence intervals (95% CI s) for frequency of fish consumption (i.e., never to <1 time/month, 1 time/month to <1 time/week, 1 time/week, and ≥2 times/week) on baseline Disease Activity Score in 28 joints ( DAS 28) using the C‐reactive protein ( CRP ) level. We also estimated the difference in DAS 28‐ CRP associated with increasing fish consumption by 1 serving per week. Results Among 176 participants, the median DAS 28‐ CRP score was 3.5 (interquartile range 2.9–4.3). In an adjusted linear regression model, subjects consuming fish ≥2 times/week had a significantly lower DAS 28‐ CRP compared with subjects who ate fish never to <1 time/month (difference −0.49 [95% CI −0.97, −0.02]). For each additional serving of fish per week, DAS 28‐ CRP was significantly reduced by 0.18 (95% CI −0.35, −0.004). Conclusion Our findings suggest that higher intake of fish may be associated with lower disease activity in RA patients.