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Cutaneous and Systemic Findings Associated With Nuclear Matrix Protein 2 Antibodies in Adult Dermatomyositis Patients
Author(s) -
Rogers Anna,
Chung Lorinda,
Li Shufeng,
CasciolaRosen Livia,
Fiorentino David F.
Publication year - 2017
Publication title -
arthritis care and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.032
H-Index - 163
eISSN - 2151-4658
pISSN - 2151-464X
DOI - 10.1002/acr.23210
Subject(s) - medicine , dermatomyositis , myalgia , anti nuclear antibody , peripheral edema , connective tissue disease , antibody , overlap syndrome , gastroenterology , systemic disease , dysphagia , pathology , malignancy , autoantibody , immunology , dermatology , immunopathology , autoimmune disease , disease , surgery , adverse effect
Objective To characterize the cutaneous and systemic clinical phenotype of dermatomyositis patients with antinuclear matrix protein 2 (anti–NXP‐2) antibodies. Methods We conducted a retrospective cohort analysis of 178 dermatomyositis patients seen at the Stanford University Clinic. An electronic chart review employing a keyword search strategy was performed to collect clinical and laboratory data. Anti–NXP‐2 antibodies were assayed by immunoprecipitation using NXP‐2 produced by in vitro transcription/translation. Results Antibodies to NXP‐2 were detected in 20 of the 178 patients (11%). Anti–NXP‐2 antibodies were associated with male sex (50% versus 25%; P = 0.02), dysphagia (74% versus 39%; P = 0.006), myalgia (89% versus 52%; P = 0.002), peripheral edema (35% versus 11%; P = 0.016), and calcinosis (37% versus 11%; P = 0.007). These patients were less likely to be clinically amyopathic (5% versus 23%; P = 0.08). Five of the 20 patients with anti–NXP‐2 antibodies (25%) had an associated internal malignancy. No other cutaneous characteristics were associated with anti–NXP‐2 antibodies, except a decreased frequency of Gottron's sign (44% versus 75%; P = 0.012) and a greater likelihood of having mild skin disease. Conclusion Dermatomyositis patients with anti–NXP‐2 antibodies have a distinct and often severe systemic phenotype that includes myalgia, peripheral edema, and significant dysphagia, despite having milder inflammatory skin disease.