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Predictors of Reduced Health‐Related Quality of Life in Adult Patients With Idiopathic Inflammatory Myopathies
Author(s) -
Feldon Michal,
Farhadi Payam Noroozi,
Brunner Hermine I.,
Itert Lukasz,
Goldberg Bob,
Faiq Abdullah,
Wilkerson Jesse,
Rose Kathryn M.,
Rider Lisa G.,
Miller Frederick W.,
Giannini Edward H.
Publication year - 2017
Publication title -
arthritis care and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.032
H-Index - 163
eISSN - 2151-4658
pISSN - 2151-464X
DOI - 10.1002/acr.23198
Subject(s) - medicine , rheumatoid arthritis , quality of life (healthcare) , myositis , dermatomyositis , population , disease , interstitial lung disease , physical therapy , inclusion body myositis , connective tissue disease , polypharmacy , autoimmune disease , lung , nursing , environmental health
Objective Extensive studies on health‐related quality of life ( HRQ oL) in idiopathic inflammatory myopathies ( IIM s) are lacking. Our objective was to document HRQ oL and to identify factors associated with a reduced HRQ oL in patients with IIM . Methods A total of 1,715 patients (median age 49.9 years, 70% female, 87% white) who met probable or definite Bohan and Peter criteria or Griggs criteria for myositis were included from the Myovision registry. HRQ oL was ascertained using the Short Form 12 ( SF ‐12) health survey questionnaire. HRQ oL physical component summary ( PCS ) and mental component summary ( MCS ) scores in relation to different patient and disease characteristics were compared to scores from matched normative data from the US general population and rheumatoid arthritis ( RA ) patients. Bivariate and multiple linear regression analyses were performed to assess the association between HRQ oL and patient and disease parameters. Results The mean SF ‐12 summary scores were significantly lower in IIM patients than in the normative and RA populations. A diagnosis of inclusion body myositis, older age, patient‐reported negative effect of disease on work, presence of another co‐occurring autoimmune disease, polypharmacy, and IIM ‐associated lung disease and joint involvement were significantly associated with lower PCS scores. Lower MCS scores were associated with joint involvement and a negative effect of disease on work. Conclusion In this large study of patient‐reported outcomes in IIM , an association was found between multiple disease characteristics and reduced HRQ oL, mostly in the physical domain. In the US , the HRQ oL of IIM patients was found to be lower than that of the general population and RA patients.