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Exercise in Takayasu Arteritis: Effects on Inflammatory and Angiogenic Factors and Disease‐Related Symptoms
Author(s) -
Oliveira Diego S.,
Shinjo Samuel K.,
Silva Marilda G.,
de SáPinto Ana L.,
Lima Fernanda R.,
Roschel Hamilton,
Mello Suzana B. V.,
CostaHong Valéria,
Irigoyen Maria C. C.,
Pereira Rosa M.,
Gualano Bruno
Publication year - 2017
Publication title -
arthritis care and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.032
H-Index - 163
eISSN - 2151-4658
pISSN - 2151-464X
DOI - 10.1002/acr.23011
Subject(s) - medicine , aerobic exercise , proinflammatory cytokine , cytokine , tumor necrosis factor alpha , vascular endothelial growth factor , physical therapy , inflammation , vegf receptors
Objective To investigate the effects of acute and chronic exercise in female patients with remissive Takayasu arteritis (TAK). Methods This was a 2‐part prospective study. In study 1, cytokines and soluble tumor necrosis factor (TNF) receptors were assessed at rest and every 60 minutes during a 3‐hour recovery period following an acute exercise session in TAK (n = 11) and heathy control (n = 10) groups. In study 2, a subsample from the TAK group (n = 6) underwent a 12‐week exercise training program. Before and after training, the acute session of aerobic exercise was performed and cytokines and soluble TNF receptors were assessed at the same time points described above. Muscle function, strength, aerobic capacity, endothelial function, quality of life, and walking impairment scores were evaluated. Results In study 1, the acute session of aerobic exercise led to overall similar responses on cytokine kinetics in the TAK and heathy control groups. In study 2, the exercise training program did not exacerbate inflammatory cytokines in TAK patients, while the proinflammatory cytokine TNF was diminished both at rest and following the acute session of aerobic exercise. In addition, the exercise training program increased the pro‐angiogenic factors vascular endothelial growth factor (at rest) and platelet‐derived growth factor AA (at rest and in response to the acute session of aerobic exercise). The exercise training program improved muscle strength and function, whereas aerobic capacity, quality of life, and endothelial function parameters remained unchanged. Conclusion Exercise could be a well‐tolerated, safe, and effective intervention able to induce immunomodulatory and pro‐angiogenic effects and to increase strength and function in patients with TAK.