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Reduced Aerobic Capacity and Quality of Life in Physically Inactive Patients With Systemic Lupus Erythematosus With Mild or Inactive Disease
Author(s) -
Pinto Ana J.,
Miyake Cintia N. H.,
Benatti Fabiana B.,
Silva Clovis A.,
Sallum Adriana M. E.,
Borba Eduardo,
de SáPinto Ana L.,
Bonfá Eloisa,
Gualano Bruno
Publication year - 2016
Publication title -
arthritis care and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.032
H-Index - 163
eISSN - 2151-4658
pISSN - 2151-464X
DOI - 10.1002/acr.22905
Subject(s) - medicine , quality of life (healthcare) , rheumatology , body mass index , disease , systemic lupus erythematosus , confidence interval , lupus erythematosus , systemic disease , immunology , nursing , antibody
Objective To compare aerobic capacity and health‐related quality of life (HRQOL) in physically inactive adult systemic lupus erythematosus (A‐SLE) and childhood‐onset systemic lupus erythematosus (C‐SLE) patients with mild/inactive disease versus healthy controls. Methods In a cross‐sectional study, 39 patients (C‐SLE: n = 18, ages 9–18 years; and A‐SLE: n = 21, ages 23–45 years) with inactive disease activity (Systemic Lupus Erythematosus Disease Activity Index ≤4) and low cumulative damage (Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index ≤2) and 30 healthy controls (15 children and adolescents [C‐CTRL], 15 adults [A‐CTRL]) matched by physical inactivity, age, sex, and body mass index (BMI) were assessed for aerobic capacity and HRQOL. Results All participants were considered physically inactive according to physical activity guidelines. C‐SLE and A‐SLE patients showed lowerVO 2 peak(95% CI confidence interval [95% CI] −10.5, −1.2 and −11.1, −3.8, respectively) and higher time‐to‐exhaustion when compared with C‐CTRL and A‐CTRL (95% CI −2.8, 0.1 and −3.9, −1.7, respectively). C‐SLE patients showed significantly lower scores in scholar functioning from the Pediatric Quality of Life Inventory questionnaire ( P < 0.05) whereas A‐SLE patients showed lower scores in most domains of the Short Form 36 health survey questionnaire (physical function, role‐physical, bodily pain, general health, vitality, social function, and mental health) when compared with healthy controls ( P < 0.05 for all). Conclusion Our study provides novel data suggesting that A‐SLE and C‐SLE patients with mild/inactive disease have impaired aerobic capacity and HRQOL when compared with controls matched by physical inactivity, age, sex, and BMI. These findings reinforce the recommendation of physical activity in SLE treatment.