Premium
Epidemiology and Characteristics of Kikuchi‐Fujimoto Disease in the African‐Descent Population of Martinique, French West Indies
Author(s) -
Moinet Florence,
Molinié Vincent,
Béraud Guillaume,
Polomat Katlyne,
Cordel Nadège,
SainteMarie Dominique,
Duffas Olivier,
Duflo Suzy,
Bomahou Charlène,
Arfi Serge,
Deligny Christophe
Publication year - 2016
Publication title -
arthritis care and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.032
H-Index - 163
eISSN - 2151-4658
pISSN - 2151-464X
DOI - 10.1002/acr.22898
Subject(s) - martinique , medicine , epidemiology , population , systemic lupus erythematosus , incidence (geometry) , lupus erythematosus , disease , demography , dermatology , west indies , immunology , environmental health , ethnology , physics , antibody , optics , history , sociology
Objective To provide an epidemiologic description of Kikuchi‐Fujimoto disease (KFD), and to describe its relationship with systemic lupus erythematosus (SLE) in a population of sub‐Saharan origin. Methods Patients were retrospectively included on the basis of lymph node histology compatible with KFD reported in Martinique from 1991 until 2013. In order to describe the characteristics of the disease in a larger cohort, we subsequently included more patients of Afro‐Caribbean origin from Guadeloupe and French Guiana. Results In Martinique, mean annual incidence between 1991 and 2013 was 2.78 cases for 1 million inhabitants (95% confidence interval 1.73–3.93). A total of 36 Afro‐Caribbean patients from the 3 French American regions were included. Mean age was 30.5 years (range 5–59 years) and the female:male ratio was 3:1. The main characteristics were cervical adenopathies (88.8%), fever (83.3%), asthenia (73.0%), weight loss (64.4%), and recurrence in 33.3%. KFD was associated with lupus (n = 9 for SLE, n = 2 for cutaneous lupus) in 36.6% (11 of 30). Conclusion We report the first epidemiologic description of KFD in a population of sub‐Saharan origin. According to our data, this disease is present in the black African diaspora and is strongly associated with autoimmune diseases, particularly lupus.