Premium
Relationship Between Disease Characteristics and Oral Radiologic Findings in Systemic Sclerosis: Results From a Canadian Oral Health Study
Author(s) -
Baron Murray,
Hudson Marie,
Dagenais Marie,
M David,
Gyger Geneviève,
El Sayegh Tarek,
Pope Janet,
Fontaine Audrey,
Masetto Ariel,
Matthews Debora,
Sutton Evelyn,
Thie Norman,
Jones Niall,
Copete Maria,
Kolbinson Dean,
Markland Janet,
NogueiraFilho Getulio,
Robinson David,
Fritzler Marvin,
Wang Mianbo,
Gornitsky Mervyn
Publication year - 2016
Publication title -
arthritis care and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.032
H-Index - 163
eISSN - 2151-4658
pISSN - 2151-464X
DOI - 10.1002/acr.22739
Subject(s) - medicine , systemic disease , scleroderma (fungus) , disease , confidence interval , univariate analysis , gingivitis , multivariate analysis , cohort , relative risk , dentistry , surgery , pathology , inoculation
Objective Systemic sclerosis (SSc; scleroderma) is associated with a wide periodontal ligament (PDL) and mandibular erosions. We investigated the clinical correlates of SSc with these radiologic abnormalities. Methods Subjects from the Canadian Scleroderma Research Group cohort underwent detailed radiologic examinations. Associations between radiologic abnormalities and clinical manifestations of SSc were examined with univariate and multivariate analyses. Results The study included 159 subjects; 90.6% were women, the mean ± SD age was 56 ± 10 years, diffuse disease was present in 28.3%, and mean ± SD disease duration was 13.7 ± 8.4 years. Widening of the PDL involving at least 1 tooth was present in 38% of subjects, and 14.5% had at least 1 site in the mandible with an erosion. In analyses adjusting for age, disease duration, sex, smoking, and education, we found significant associations between the number of teeth with widening of the PDL and disease severity assessed by the physician global assessment (PGA) (relative risk [RR] 1.19, 95% confidence interval [95% CI] 1.02–1.39, P = 0.028). Analyses replacing the PGA with the skin score, disease subset, or anti–topoisomerase I antibodies confirmed the relationship with indices of disease severity. There was no relationship between either the number of teeth with periodontal disease or the number of missing teeth, and the number of teeth with wide PDL. A smaller interdental distance (RR 0.89, 95% CI 0.82–0.97, P = 0.006), but not disease severity, facial skin score, or ischemia was associated with a larger number of erosions. Conclusion In SSc, a wide PDL may reflect generalized overproduction of collagen, and mandibular erosions are related to local factors in the oral cavity.