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Traditional Cardiovascular Risk Factors and Coronary Artery Calcification in Adults With Polymyositis and Dermatomyositis: A Danish Multicenter Study
Author(s) -
Diederichsen Louise P.,
Diederichsen Axel C. P.,
Simonsen Jane A.,
Junker Peter,
Søndergaard Klaus,
Lundberg Ingrid E.,
Tvede Niels,
Gerke Oke,
Christensen Anne F.,
Dreyer Lene,
Petersen Henrik,
Ejstrup Leif,
Kay Susan D.,
Jacobsen Søren
Publication year - 2015
Publication title -
arthritis care and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.032
H-Index - 163
eISSN - 2151-4658
pISSN - 2151-464X
DOI - 10.1002/acr.22520
Subject(s) - medicine , polymyositis , diabetes mellitus , dermatomyositis , risk factor , cardiology , danish , agatston score , multivariate analysis , coronary artery disease , coronary artery calcium , endocrinology , philosophy , linguistics
Objective To determine the occurrence of traditional cardiovascular (CV) risk factors and coronary artery calcification (CAC) in adults with polymyositis (PM) or dermatomyositis (DM) compared to healthy controls and to assess the association between CV risk factors, PM/DM, and CAC score. Methods Traditional CV risk factors were assessed in a cross‐sectional, observational study of 76 patients with PM/DM and in 48 sex‐ and age‐matched healthy controls. CAC was quantified by means of cardiac computed tomography scan and expressed in Agatston units. The associations between CV risk factors, PM/DM, and CAC were studied by multivariate analyses. Results Thirty‐three percent of the patients were obese compared to 11% of the controls ( P = 0.005). Hypertension and diabetes mellitus were more frequent in patients (71% versus 42%; P = 0.002, and 13% versus 0%; P = 0.007), and patients had higher levels of triglycerides ( P = 0.0009). High CAC score occurred more frequently in patients (20% versus 4%; P = 0.04). In multivariate analysis of patient factors associated with CAC were age ( P = 0.02) and smoking ( P = 0.02). Conclusion In this study, traditional CV risk factors and severe CAC were commonly found in patients with PM/DM. However, severe CAC was not associated with PM/DM per se, but rather with age and smoking in these patients.