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Construct Validity of the Patient‐Reported Outcomes Measurement Information System Gastrointestinal Symptom Scales in Systemic Sclerosis
Author(s) -
Nagaraja Vivek,
Hays Ron D.,
Khanna Puja P.,
Spiegel Brennan M. R.,
Chang Lin,
Melmed Gil Y.,
Bolus Roger,
Khanna Dinesh
Publication year - 2014
Publication title -
arthritis care and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.032
H-Index - 163
eISSN - 2151-4658
pISSN - 2151-464X
DOI - 10.1002/acr.22337
Subject(s) - medicine , discriminant validity , construct validity , bloating , patient reported outcomes measurement information system , physical therapy , population , quality of life (healthcare) , irritable bowel syndrome , nausea , psychometrics , gastroenterology , clinical psychology , computerized adaptive testing , internal consistency , nursing , environmental health
Objective Gastrointestinal (GI) involvement is common in patients with systemic sclerosis (SSc; scleroderma). The Patient‐Reported Outcomes Measurement Information System (PROMIS) GI symptom item bank captures upper and lower GI symptoms (reflux, disrupted swallowing, nausea/vomiting, belly pain, gas/bloating/flatulence, diarrhea, constipation, and fecal incontinence). The objective of this study was to evaluate the construct validity of the PROMIS GI bank in SSc. Methods A total of 167 patients with SSc were administered the PROMIS GI bank and the University of California, Los Angeles, Scleroderma Clinical Trials Consortium Gastrointestinal Scale (GIT 2.0) instrument. GIT 2.0 is a multi‐item instrument that measures SSc‐associated GI symptoms. Product‐moment correlations and a multitrait–multimethod analysis of the PROMIS GI scales with the GIT 2.0 symptom scales were used to evaluate convergent and discriminant validity. Results Patients with SSc GI involvement had PROMIS GI scale scores 0.2–0.7 SD worse than the US general population. Correlations among scales measuring the same domains for the PROMIS GI and GIT 2.0 measures were large, ranging from 0.61 to 0.87 (average r = 0.77). The average correlation between different symptom scales was 0.22, supporting discriminant validity. Conclusion This study provides support for the construct validity of the PROMIS GI scales in SSc. Future research is needed to assess the responsiveness to change of these scales in patients with SSc.