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Clinical Features and Outcomes of Posterior Reversible Encephalopathy Syndrome in Patients With Systemic Lupus Erythematosus
Author(s) -
Lai ChienChih,
Chen WeiSheng,
Chang YuSheng,
Wang ShuHung,
Huang ChunJui,
Guo WanYuo,
Yang WuChang,
Huang DeFeng
Publication year - 2013
Publication title -
arthritis care and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.032
H-Index - 163
eISSN - 2151-4658
pISSN - 2151-464X
DOI - 10.1002/acr.22047
Subject(s) - medicine , hypoalbuminemia , posterior reversible encephalopathy syndrome , odds ratio , gastroenterology , confidence interval , thrombotic microangiopathy , disease , magnetic resonance imaging , radiology
Objective To analyze the clinical features and outcomes of patients with posterior reversible encephalopathy syndrome (PRES), the risk factors of PRES‐related intracranial hemorrhage (ICH), and all‐cause mortality in patients with systemic lupus erythematosus (SLE). Methods Twenty‐six episodes of PRES were identified in 23 SLE patients, using an electronic medical records database of 3,746 SLE patients. Results The prevalence of PRES was 0.69% among SLE patients. The scores of the SLE Disease Activity Index without neurologic descriptors (SLEDAI‐N) were significantly elevated from baseline for a mean of 3.3 during PRES ( P = 0.009). Rapidly deteriorating renal function, pulmonary hemorrhage, thrombotic microangiopathy, macrophage activation syndrome, or multiple organ dysfunction syndrome appeared during 65.4% of episodes. In 16 episodes, patients completely recovered from PRES‐related symptoms within a median of 7 days. Visual impairment was reversed within 2 days in 8 of 15 patients, but impairment in other patients was protracted for up to 4 months, especially when ICH was present. Hypoalbuminemia (<20 gm/liter; odds ratio [OR] 30, 95% confidence interval [95% CI] 2.04–441.84) and thrombocytopenia (<30,000/mm 3 ; OR 21, 95% CI 1.27–346.93) were risk factors for PRES‐related ICH. Patients with SLEDAI‐N scores >18 during a PRES attack had significantly higher mortality rates than did patients with SLEDAI‐N scores ≤18 ( P = 0.009 by log rank test). Conclusion PRES frequently occurs during active SLE with multiple complications. Hypoalbuminemia and thrombocytopenia may contribute to PRES‐related ICH. The extraneurologic disease activity of lupus during PRES may influence the mortality rate of SLE patients.