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Occurrence of Radiographic Osteoarthritis of the Knee and Hip Among African Americans and Whites: A Population‐Based Prospective Cohort Study
Author(s) -
Kopec Jacek A.,
Sayre Eric C.,
Schwartz Todd A.,
Renner Jordan B.,
Helmick Charles G.,
Badley Elizabeth M.,
Cibere Jolanda,
Callahan Leigh F.,
Jordan Joanne M.
Publication year - 2013
Publication title -
arthritis care and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.032
H-Index - 163
eISSN - 2151-4658
pISSN - 2151-464X
DOI - 10.1002/acr.21924
Subject(s) - medicine , osteoarthritis , hazard ratio , incidence (geometry) , confidence interval , prospective cohort study , cohort , radiography , cohort study , population , body mass index , physical therapy , surgery , pathology , physics , alternative medicine , environmental health , optics
Objective To compare the incidence and progression of radiographic osteoarthritis (OA) in the knee and hip among African Americans and whites. Methods Using the joint as the unit of analysis, we analyzed data from the Johnston County Osteoarthritis Project, a population‐based prospective cohort study in rural North Carolina. Baseline and followup assessments were 3–13 years apart. Assessments included standard knee and hip radiographs read for Kellgren/Lawrence (K/L) radiographic grade. Weighted analyses controlled for age, sex, body mass index, level of education, and baseline K/L grade; bootstrap methods adjusted for lack of independence between left and right joints. Time‐to‐event analysis was used to analyze the data. Results For radiographic knee OA, being African American had no association with incidence (adjusted hazard ratio [HR adj ] 0.80, 95% confidence interval [95% CI] 0.53–1.22), but had a positive association with progression (HR adj 1.67, 95% CI 1.05–2.67). For radiographic hip OA, African Americans had a significantly lower incidence (HR adj 0.44, 95% CI 0.27–0.71), whereas the association with progression was positive but nonsignificant (HR adj 1.46, 95% CI 0.53–4.01). In sensitivity analyses, the association with hip OA incidence was robust to a wide range of assumptions. Conclusion African Americans are protected against incident hip OA, but may be more susceptible to progressive knee OA.