Premium
Use of a disease risk score to compare serious infections associated with anti–tumor necrosis factor therapy among high‐ versus lower‐risk rheumatoid arthritis patients
Author(s) -
Curtis Jeffrey R.,
Xie Fenglong,
Chen Lang,
Muntner Paul,
Grijalva Carlos G.,
Spettell Claire,
Fernandes Joaquim,
Mcmahan Raechele M.,
Baddley John W.,
Saag Kenneth G.,
Beukelman Timothy,
Delzell Elizabeth
Publication year - 2012
Publication title -
arthritis care and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.032
H-Index - 163
eISSN - 2151-4658
pISSN - 2151-464X
DOI - 10.1002/acr.21805
Subject(s) - etanercept , adalimumab , medicine , infliximab , rheumatoid arthritis , comorbidity , risk factor , disease
Objective To evaluate whether rates of serious infection with anti–tumor necrosis factor (anti‐TNF) therapy in rheumatoid arthritis (RA) patients differ in magnitude by specific drugs and patient characteristics. Methods Among new nonbiologic disease‐modifying antirheumatic drug users enrolled in Medicare and Medicaid or a large US commercial health plan, we created and validated a person‐specific infection risk score based on age, demographics, insurance type, glucocorticoid dose, and comorbidities to identify patients at high risk for hospitalized infections. We then applied this risk score to new users of infliximab, etanercept, and adalimumab and compared the observed 1‐year rates of infection to one another and to the predicted infection risk score estimated in the absence of anti‐TNF exposure. Results Among 11,657 RA patients initiating anti‐TNF therapy, the observed 1‐year rate of infection was 14.2 infections per 100 person‐years in older patients (age ≥65 years) and 4.8 in younger patients (age <65 years). There was a relatively constant rate difference of ∼1–4 infections per 100 person‐years associated with anti‐TNF therapy across the range of the infection risk score. Infliximab had a significantly greater adjusted rate of infection compared to etanercept and adalimumab in both high‐ and lower‐risk RA patients. Conclusion The rate of serious infections for anti‐TNF agents was incrementally increased by a fixed absolute difference irrespective of age, comorbidities, and other factors that contributed to infections. Older patients and those with high comorbidity burdens should be reassured that the magnitude of their incremental risk with anti‐TNF agents is not greater than for lower‐risk patients.