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Exercise training in juvenile dermatomyositis
Author(s) -
Omori Clarissa Harumi,
Silva Clovis Artur Almeida,
Sallum Adriana Maluf Elias,
Rodrigues Pereira Rosa Maria,
Lúciade Sá Pinto Ana,
Roschel Hamilton,
Gualano Bruno
Publication year - 2012
Publication title -
arthritis care and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.032
H-Index - 163
eISSN - 2151-4658
pISSN - 2151-464X
DOI - 10.1002/acr.21684
Subject(s) - juvenile dermatomyositis , medicine , juvenile , physical therapy , quality of life (healthcare) , aerobic exercise , vo2 max , cardiorespiratory fitness , statistical significance , strength training , heart rate , dermatomyositis , blood pressure , nursing , genetics , biology
Objective To investigate the effects of a supervised exercise training program on health parameters, physical capacity, and health‐related quality of life in patients with mild and chronic juvenile dermatomyositis (DM). Methods This was a prospective longitudinal study following 10 children with mild and chronic juvenile DM (disease duration >1 year). The exercise program consisted of twice‐a‐week aerobic and resistance training. At baseline and after the 12‐week intervention, we assessed muscle strength and function, aerobic conditioning, body composition, juvenile DM scores, and health‐related quality of life. Results Child self‐report and parent proxy‐report Pediatric Quality of Life Inventory scores were improved after the intervention (−40.3%; P = 0.001 and −48.2%; P = 0.049, respectively). Importantly, after exercise, the Disease Activity Score was reduced (−26.9%; P = 0.026) and the Childhood Muscle Assessment Scale was improved (+2.5%; P = 0.009), whereas the Manual Muscle Test presented a trend toward statistical significance (+2.2%; P = 0.081). The peak oxygen consumption and time‐to‐exhaustion were increased by 13.3% ( P = 0.001) and 18.2% ( P = 0.003), respectively, whereas resting heart rate was decreased by 14.7% ( P = 0.006), indicating important cardiovascular adaptations to the exercise program. Upper and lower extremity muscle strength and muscle function were also significantly improved after the exercise training ( P < 0.05). Both the whole‐body and the lumbar spine bone mineral apparent density were significantly increased after training (1.44%; P = 0.044 and 2.85%; P = 0.008, respectively). Conclusion We showed for the first time that a 12‐week supervised exercise program is safe and can improve muscle strength and function, aerobic conditioning, bone mass, disease activity, and health‐related quality of life in patients with active and nonactive mild and chronic juvenile DM with near normal physical function and quality of life.