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Azathioprine in severe uveitis of Behçet's disease
Author(s) -
Saadoun D.,
Wechsler B.,
Terrada C.,
Hajage D.,
Le Thi Huong D.,
RescheRigon M.,
Cassoux N.,
Le Hoang P.,
Amoura Z.,
Bodaghi B.,
Cacoub P.
Publication year - 2010
Publication title -
arthritis care and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.032
H-Index - 163
eISSN - 2151-4658
pISSN - 2151-464X
DOI - 10.1002/acr.20308
Subject(s) - azathioprine , medicine , retinal vasculitis , uveitis , prednisone , behcet's disease , gastroenterology , odds ratio , vasculitis , visual acuity , surgery , disease , ophthalmology
Objective To investigate the efficacy and tolerance of azathioprine in severe uveitis related to Behçet's disease (BD). Methods We reported 157 consecutive patients with severe uveitis (active posterior uveitis or panuveitis) fulfilling the international criteria for BD and treated with corticosteroids (0.5–1 mg/kg/day) and azathioprine (2.5 mg/kg/day). Long‐term outcome and factors associated with complete remission were assessed. Results Mean ± SD age at diagnosis was 29.9 ± 10.1 years, with 71.3% men. At baseline, 59 patients (37.6%) had loss of useful vision, 54 (34.4%) had retinal vasculitis, 66 (42.0%) had panuveitis, and 132 (84.1%) had bilateral uveitis. Following azathioprine therapy, 81 patients (51.6%) were complete responders, 65 (41.4%) were partial responders, and 11 (7%) were nonresponders. The visual acuity significantly improved ( P < 0.001), and a significant decrease in the mean oral prednisone dosage (55.3 to 10.5 mg/day; P < 0.001) was observed after therapy. Patients with retinal vasculitis (odds ratio [OR] 0.45 [95% confidence interval (95% CI) 0.2–0.9], P = 0.02) and severe visual loss (OR 0.28 [95% CI 0.2–0.7], P < 0.0001) at diagnosis were less likely to be complete responders. Azathioprine was well tolerated, with only 3 withdrawals due to hepatotoxic effects (n = 2) and bacterial septicemia (n = 1). Conclusion Azathioprine represents an effective and safe therapy in patients with severe uveitis of BD.