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Accurate detection of changes in disease activity in primary Sjögren's syndrome by the European League Against Rheumatism Sjögren's Syndrome Disease Activity Index
Author(s) -
Seror Raphaèle,
Mariette Xavier,
Bowman Simon,
Baron Gabriel,
Gottenberg Jacques Eric,
Boostma Hendrika,
Theander Elke,
Tzioufas Athanasios,
Vitali Claudio,
Ravaud Philippe
Publication year - 2010
Publication title -
arthritis care and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.032
H-Index - 163
eISSN - 2151-4658
pISSN - 2151-464X
DOI - 10.1002/acr.20173
Subject(s) - rheumatism , medicine , disease , systemic disease , gastroenterology
Objective To assess and compare the sensitivity to change of the European League Against Rheumatism Sjögren's Syndrome Disease Activity Index (ESSDAI) with that of other primary Sjögren's syndrome (SS) disease activity indexes. Methods We abstracted 96 patient profiles, including data on 3 successive visits (visits 1–3), from the medical charts of patients with primary SS. Patient profiles were scored with the ESSDAI, SS Disease Activity Index (SSDAI), and Sjögren's Systemic Clinical Activity Index (SCAI). Thirty‐nine experts assessed 5 profiles for whether disease activity had improved, worsened, or remained stable at visits 2 and 3. Results For improved patients, the standardized response means (SRMs) for all scores did not differ, and ranged from −1.08 to −1.38 between visits 1 and 2 and from −0.50 to −0.76 between visits 2 and 3. For patients with worsened activity, the SRMs between visits 1 and 2 and between visits 2 and 3 were +0.46 and +1.10 for the ESSDAI, −0.03 and +0.79 for the SSDAI, and +0.17 and +1.02 for the SCAI, respectively. For patients with stable activity, the SRMs between visits 1 and 2 and between visits 2 and 3 were 0.00 and −0.13 for the ESSDAI, −0.44 and −0.11 for the SSDAI, and −0.36 and +0.34 for the SCAI, respectively. Conclusion For patients with improved activity, the 3 disease activity indexes showed similar, large sensitivity to change. However, the ESSDAI seemed to detect changes in activity more accurately than other disease activity indexes. Notably, for patients with stable activity, the ESSDAI did not show erroneous improvement.

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