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Objectives  High‐frequency spinal cord stimulation ( HF ‐ SCS ) at 10  kH z has proven to be efficacious in the treatment of chronic back and leg pain in a randomized, controlled, trial ( SENZA ‐ RCT ). However, large observational studies have yet to be published. Therefore, we performed a real‐world, multicenter, retrospective, review of therapy efficacy in 1660 patients with chronic trunk and/or limb pain.    Methods  Data were collected in a real‐world environment and retrospectively sourced from a global database. Included patients were trialed and/or permanently implanted with  HF ‐ SCS  at 10  kH z between April 2014 and January 2018. We evaluated responder rates at 3, 6, and 12 months post‐implantation. Response was defined as ≥50% pain relief from baseline. A last visit analysis included responder rate along with overall change in function, sleep, quality of life, and medication intake versus baseline.    Results  Eighty‐four percent of our  HF ‐ SCS ‐treated patients had both chronic back and leg pain. At least 70% of patients reported response to therapy throughout 12 months of follow‐up. This sustained responder rate was corroborated by the last visit value (74.1%). Most patients reported concomitant improvements in function (72.3%), sleep (68.0%), and quality of life (90.3%) at their last visit versus baseline. Thirty‐two percent of patients reported decreased medication intake at their last visit.    Interpretation  Sustained and effective pain relief was experienced by >70% of our  HF ‐ SCS ‐treated patients, consistent with the findings of a previously published randomized, controlled, trial. Our review provides complementary evidence to support the treatment of chronic back and leg pain with this therapy.

A multicenter real‐world review of 10 kH z SCS outcomes for treatment of chronic trunk and/or limb pain