English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

Objective  Intracerebral hemorrhage carries a high mortality and survivors are frequently left with significant disability. Immunological mechanisms may play an important role in hemorrhage‐induced brain injury, however, research linking these mechanisms with clinical outcome remains limited. We aim to identify serum inflammatory mediators that are associated with outcome after intracerebral hemorrhage in order to translate data from experimental models to a patient cohort and identify potential targets worthy of reverse translation.    Methods  A prospective cohort study at two comprehensive stroke centers enrolled patients with spontaneous intracerebral hemorrhage. Peripheral blood was collected at 6, 24, and 72 h from onset. Functional outcome was assessed at 90 days using the modified Rankin Scale ( mRS ). Serum inflammatory mediators were measured using multiplex  ELISA . Multivariable modeling identified serum biomarkers independently associated with functional outcome at 90 days.    Results  115 patients completed the study. At 6 h after onset, patients with elevated  CCL 2 had worse  mRS  score at day 90 ( OR  4.07, 95%  CI  1.27–13.10,  P  = 0.02) after adjusting for age, gender,  ICH  volume,  IVH , infratentorial location and  NIHSS  score. At 24 and 72 h after onset, elevation in  CXCL 10 was independently associated with worse 90 days  mRS  score (24 h:  OR  8.08, 95%  CI  2.69–24.30,  P  < 0.001; 72 h:  OR  3.89, 95%  CI  1.12–13.49,  P  = 0.03).    Interpretation  Acute and subacute elevations in specific immune factors are associated with poor outcome, highlighting potential pathways that may contribute to ongoing brain injury in patients with intracerebral hemorrhage.

CCL 2 and CXCL 10 are associated with poor outcome after intracerebral hemorrhage