Open AccessAccelerated long‐term forgetting over three months in asymptomatic APOE ɛ4 carriers
Author(s) -
TortMerino Adrià,
Laine Matti,
Valech Natalia,
Olives Jaume,
León María,
EcayTorres Mirian,
Estanga Ainara,
MartínezLage Pablo,
Fortea Juan,
SánchezValle Raquel,
Rami Lorena,
RodríguezFornells Antoni
Publication year - 2021
Publication title -
annals of clinical and translational neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.824
H-Index - 42
ISSN - 2328-9503
DOI - 10.1002/acn3.51245
Subject(s) - medicine , forgetting , apolipoprotein e , cerebrospinal fluid , asymptomatic , pathophysiology , asymptomatic carrier , disease , gastroenterology , psychology , cognitive psychology
Accelerated long‐term forgetting (ALF) refers to a rapid loss of information over days or weeks despite normal acquisition/encoding. Notwithstanding its potential relevance as a presymptomatic marker of cognitive dysfunction, no study has addressed the relationship between ALF and Alzheimer’s disease (AD) biomarkers. We examined ALF in APOE ɛ4 carriers versus noncarriers, and its relationships with AD cerebrospinal fluid (CSF) biomarkers. We found ALF over three months in APOE ɛ4 carriers ( F (1,19) = 5.60; P < 0.05; Cohen’s d = 1.08), and this performance was associated with abnormal levels of the CSF Aβ 42 /ptau ratio (r = −.614; P < 0.01). Our findings indicate that ALF is detectable in at‐risk individuals, and that there is a relationship between ALF and the pathophysiological processes underlying AD.