Open AccessTranscranial magnetic stimulation tracks subminute changes in cortical excitability during propofol anesthesia
Author(s) -
Gersner Roman,
Paredes Carmen,
Hameed Mustafa Q.,
Dhamne Sameer C.,
PascualLeone Alvaro,
Rotenberg Alexander
Publication year - 2020
Publication title -
annals of clinical and translational neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.824
H-Index - 42
ISSN - 2328-9503
DOI - 10.1002/acn3.50981
Subject(s) - propofol , medicine , transcranial magnetic stimulation , anesthesia , electromyography , bolus (digestion) , stimulation , pulse (music) , physical medicine and rehabilitation , surgery , computer science , telecommunications , detector
Automated anesthesia systems that continuously monitor cortical excitability (CE) changes to govern drug infusion rates, are desirable. Paired‐pulse transcranial magnetic stimulation (ppTMS), with electromyography (EMG), provides noninvasive CE measures. We tested whether, and with what temporal resolution, ppTMS‐EMG detects dose‐dependent CE in rats anesthetized with continuous intravenous propofol. Motor‐evoked potentials (MEPs) were recorded every 20 seconds as either propofol bolus or change in infusion rate was applied. ppTMS‐derived measures varied in direct proportion to propofol dose with subminute temporal resolution. We conclude that ppTMS‐EMG enables real‐time markers of target engagement by anesthetics that may be incorporated into an automated device.